Transforming Neurology with Personalized Care and Compassion

From Diagnosis to Treatment—Care That Puts You First

The Leading Neurological Care in Greenville, SC

At Premier Neurology, we believe that expert neurological care begins with compassion, innovation, and a patient-first approach.

Led by Dr. Mary Hughes, a nationally recognized leader in Multiple Sclerosis care, our team provides comprehensive, personalized neurology services designed to support your health at every stage. From cutting-edge treatments and infusion therapy to acupuncture and integrated medical care, we offer a full-service approach—all under one roof.

Whether you’re managing a complex neurological condition or seeking expert guidance, our team is here to provide leading-edge care, tailored to you.

Comprehensive Neurological Services
Multiple Sclerosis Speciality Care
Comprehensive Headache & Migraine Management
On-Site Lifestyle Infusion Services
In-Office EEG Testing
Acupuncture & Integrated Health Services

Where expertise meets empathy.

Schedule your appointment today.

Explore our

CARE CENTERS

Expert Neurological Care, Together in One Place.

Lifestyle Infusion Services

In-Office EEG

Assessment Clinic

Acupuncture

What Our Patients Say...

This is my fourth neurologist and I’m so thankful I finally found a good fit for my care team. From start to finish, each staff member I came into contact with was attentive and helpful... Together, we were able to work together to decide on next steps. I’m excited to see their acupuncture therapist, and continue to trust my care to them! I highly recommend coming here, especially if you feel weary finding a neurologist right for you!

Dr. Mary Hughes is by far the most empathetic, intelligent, encouraging doctor I have ever seen. Dr. Hughes demands the best from her staff and she provides excellent care. I’ve been a patient of Dr. Hughes for several years... If you want quality care and to be the best treatment, trust me see Dr. Hughes.

It is difficult to think of powerful enough words to describe my incredible experience. Dr. Hughes provides second-to-none professional service that would be difficult to find anywhere else. She is friendly, compassionate, sincere, and extremely knowledgeable... A+++ and would HIGHLY recommend to anyone.

Dr. Hughes and her staff was a Godsend for me and I would and have recommended them to many people who need a great neurologist!! Her and her staff are very compassionate and listen to their patients and go above and beyond to give the best care they can!

Wonderful doctors, staff fought for my medicinal needs with my insurance and went the extra effort to get my meds approved. This is a well-run, private practice that cares for the needs of each individual. Highly recommend!

If you are desiring a loving, knowledgable, caring, strong family member to be your physician, then feel welcome to Dr. Hughes' family on your first visit. Family is what you become at the first hello.

In The Community

Dr. Hughes and the Premier Neurology team are deeply involved in the Multiple Sclerosis community. Join us in fighting to create a world without MS.

Dressing up for the Joi Life Gala

Building awareness during MS Awareness Month

Dr. Hughes and Al volunteering for Walk MS

Dr. Hughes and Mel at the Oak Study Investigator Meeting

Dr. Hughes speaking at the Joi Life MS Roundtable

James volunteering at Walk MS

Loren volunteering at Walk MS

Fighting for a world without Multiple Sclerosis at the Actrims Conference

Federica presenting at the NMSS Board Meeting

Dr. Hughes, Loren, Porshia, Suzanne & Freda prepping for Walk MS

Conferences, Causes & Community Care

Our team is always learning, leading, and lending a hand. From medical conferences to community events and causes close to our hearts, we believe in showing up — for our profession and the people we serve.

We look forward to helping you live your best life.

SPEAK WITH OUR CLINIC TEAM:

864-665-4005